| Saumithraസൌമീത്രാ | Lord Lakshman son of Sumitra) |
| Sauvarസൌവാര | Belonging to sound, A musical note |
| Savantസവംത | A learned and wise scholar. |
| Savya Sachiസാവ്യ-സാചീ | Another name of Arjun, Ambidextrous |
| Savyamoonthസവയമൂനതഃ | Savyamoonth comes from An Indian word meaning, Defender of people |
| Savyashacheeസവ്യസാചീ | Ambidextrous while shooting |
| Sayshanthസയശാംത | Avatar of Lord Vishnu, Good peace |
| Selva Kumarസേലവാ കുമാര | A wealthy and prosperous young prince. |
| Selvanathnസേല്വനാഥം | Selvanathn means 'Gift of the Lord' or 'Divine Gift' in Sanskrit, a combination of Selva (Lord) and Nathn (Gift). |
| Selvianസേല്വിയന | Of or pertaining to Selvians, a people or tribe, possibly from the Latin 'selvus' meaning wild or savage. |
| Senaanyസേനാനീ | One of the kauravas |
| Senthil Kumarസേംതീല കുമാര | Lord Murugan, Always youth |
| Serasസേരസ | Derived from the Latin word 'serere,' meaning to sow or plant, often associated with fertility. |
| Seshanandസേശാനംദ | Lord Vishnu, Beloved of sesh |
| Sesuസേസു | Snake, Venkateswara |
| Sethu Lakshmiസേതു ലക്ഷ്മീ | Goddess Lakshmi, Worth |
| Setukruteസേതുകൃതേ | Builder of the bridge over ocean |
| Sewinസേവീന | Sewin is a Welsh name meaning 'little river' or 'stream', derived from the Old Welsh word 'sawyn'. |
| Shaantivശാംതിവ | One who is peaceful and calm in nature. |
| Shaastശാസ്ത | Ruler, One who commands |
| Shaastiശാസ്തീ | Command, Royal authority, Hymn, Lord Murugan, Another name for Durga |
| Shabastശാബസ്ത | Armoured, Protected |
| Shadanananശാദനാനന | Lord Subramanyan |
| Shagdavശാഗ്ദവ | Shagdav is a Mongolian name meaning 'bringer of good fortune' or 'auspicious one'. |
| Shailajശൈലജ | Daughter of the mountains |
| Shaininശൈനീന | Peaceful, Restrained |
| Shajaneeshശാജനീശ | Shajaneesh is a Sanskrit name meaning 'Victory of the Lord' or 'Triumphant Lord'. |
| Shajunanശാജുനാന | Shajunan is a variant of the name Shahjahan, meaning 'world conqueror' or 'conqueror of the world'. |
| Shakithശകിത | Shakith is a variant of Shakitha, meaning 'blessed' or 'fortunate' in Sanskrit, derived from the word 'shak' meaning 'good fortune'. |
| Shakthidharശക്തീധര | Lord Shiva, The Lord Subramanian |
| Shakunthശാകുന്ത | Derived from a bird, meaning auspicious. |
| Shakyaശക്യ | Lord Buddha, Energy circle or a form of chakra |
| Shalivahanശാലിവാഹന | Name of a famous king |
| Hari Priyaഹരീപ്രിയാ | Goddess Lakshmi, Beloved of Hari |
| Shamathശാമത | Quiet, Tranquillity, A counseller, Residing in peace, Peaceful, Calm |
| Shamenശാമേന | Holy Man, Happy, Auspicious, Security, Wealthy |
| Shamijithശമിജീത | Shamijith means 'peaceful victory' or 'victory of peace' in Malayalam, a language spoken in southern India. |
| Shammadശാമ്മദ | One who has conquered his ego |
| Shampakശമ്പക | Created by thunderbolts, Brilliant |
| Shamvatശംവത | Auspicious, Wealthy |