| Sadeeshसादिश | Lord of the entire world |
| Saharshuसहर्षु | One who is full of joy and light. |
| Sailakshmiसाईलक्ष्मी | Good Behavior; Goddess Lakshmi |
| Sakeethसकिथ | Lord Krishna; Having the same intention |
| Sameshwariसामेश्वरी | Goddess of equality and balance. |
| Sananthanसानंथन | Eternal and without a beginning. |
| Sangharshaसंघर्षा | One who faces life with struggle. |
| Sanishaसानिशा | Most Beautiful; Generous; Amazing |
| Sanmithraसंमिथरा | A true and very loyal friend. |
| Santenuसंतेनुं | One who brings peace and harmony. |
| Santhanalakshmiसंथनालक्ष्मी | Goddess of wealth and progeny. |
| Sanvinसनविन | One who is always smiling. |
| Sanvritaसांवरित | Someone who is well covered. |
| Sarabeshwarसाराबेश्वर | Lord Shiva, the supreme god. |
| Sarakshaसारक्षा | Happy; Versatile; Expressive nature |
| Sarathkumarसरथकुमार | A warrior or a good leader. |
| Sarguneshसरगुनेश | All the Quality; All Good Things |
| Sarvekshaसर्वेक्षा | Lord Ganesha; Lord of All |
| Sathyadevसाथियादेव | Lord of truth and justice. |
| Sathyasriसत्यश्री | Loyalty and truth |
| Sathyavaniसाथियावानी | One who speaks only the truth. |
| Satyanसत्यन | Lord of the truth |
| Satyendarसत्येन्द्रं | Best among truthful; Lord of truth; Lord of truth (Satyen); Lord of truth (Satyen) |
| Savyoसाव्यो | A person who is very talented. |
| Sayanthikaसायनथीका | One who brings the evening. |
| Sebatiसेबाती | A beautiful white flower. |
| Shajayaशझया | Sensitive;Entertainer; Impressive Personality |
| Shakthiveluशकथीवेलुं | Another name for God Murugan; also SakthiVelan |
| Shalwaशालवा | One who is calm and peaceful. |
| Shanhithaशाहींथा | Someone who is very kindhearted. |
| Shanjशांज | Creator of the universe; Another name for Lord Shiva; Lord Brahma |
| Shanjanaशांजना | Gentle; Creator |
| Sharaviश्रवी | An innocent and pure person. |
| Shasangशासंग | Attached; Connected; Associated |
| Shayanthशायन्तः | One who brings great victory. |
| Sheshvarशेश्वर | Lord venkateswara |
| Shidhantसिद्धांत | One who has a clear purpose. |
| Shijeshसीजेश | A person who is very creative. |
| Shimitसीमित | One who is modest and humble. |
| Shivaratriशिवरात्री | Shiva appareance |