| Sherril | Shire on a Hill |
| Sherrill | A name meaning bright or beloved meadow. |
| Shevaughn | An Irish name meaning God is gracious. |
| Shevon | A variant name meaning God is gracious. |
| Shia | A follower of the Islamic faith. |
| Shikoba | A name meaning feather or wing. |
| Shone | Yahweh is Merciful or Gracious |
| Shonti | Variant of Shonti, meaning 'peaceful' or 'calm'. |
| Shooter | One who Shoots with a Gun or Camera |
| Shorn | Having hair cut or removed, often referring to the head or face. |
| Shunda | A name meaning smooth or sleek. |
| Shyheim | Variant of Shyheim, meaning 'peaceful' or 'tranquil'. |
| Sicily | From the Island |
| Sidi | Variant of Sidi, meaning 'master' or 'lord'. |
| Sidnei | Variant of Sidney, meaning 'wide meadow'. |
| Sifis | Variant of Sifis, meaning 'wise' or 'intelligent'. |
| Sifu | Chinese term for a martial arts master or instructor. |
| Sigurjon | Icelandic name meaning 'victory' or 'triumph'. |
| Sik | Short form of Sikh, referring to a follower of Sikhism. |
| Sikki | Variant of Sikh, referring to a follower of Sikhism. |
| Silvian | Man of the Woods |
| Simos | Greek name meaning 'listener' or 'hearer'. |
| Sione | Yahweh is Merciful or Gracious |
| Siros | Greek name meaning 'man of the forest'. |
| Sirri | Beautiful Victory |
| Ski | A long runner used for gliding. |
| Skippy | One who moves with light leaps. |
| Slav | Person from Slavic countries or cultures. |
| Slave | A person held in forced service. |
| Snyder | One who works as a local tailor. |
| Sojin | Korean name meaning 'wisdom' or 'intelligence'. |
| Soldier | A person serving in an army. |
| Somar | One who is born in summer. |
| Sonn | A variant of the name John. |
| Sono | A name meaning sound or tone. |
| Spanky | One who is Outspoken or Stubborn |
| Sparky | Giving off Sparks |
| Spelman | English surname meaning 'blacksmith' or 'metalworker'. |
| Spider | Resembling the Arachnid |
| Spyder | Resembling the Arachnid |