| Ruffy | Nickname for Rufus, meaning 'wolf's friend' |
| Ruis | Short form of Russell, meaning 'fox's wisdom' |
| Rulon | Famous Landowner |
| Rummy | A person who is quite odd. |
| Russo | Someone with red colored hair. |
| Ryoga | Japanese name meaning 'good law' or 'good principle' |
| Sady | Short form of Sadie, meaning 'lady' or 'princess' |
| Sagi | Hebrew name meaning 'my prince' or 'my king' |
| Sanel | One who is a gift from God. |
| Satch | A name meaning satchel or bag. |
| Sato | Japanese name meaning 'wise' or 'intelligent' |
| Savva | Russian name meaning 'wise' or 'intelligent' |
| Sayat | Hebrew name meaning 'gift of God' |
| Saye | A Talkative Man |
| Scoot | One who Discovers |
| Scooter | One who Moves Quickly |
| Sea | The vast body of salt water. |
| Sebastain | Man from Sebasta |
| Sebastijan | Latin name meaning 'venerable' or 'revered' |
| Sedrick | Derived from Cedric, meaning kindly or loved. |
| Seng | Chinese name meaning 'good' or 'virtuous' |
| Senor | A Spanish title of respect meaning mister. |
| Serg | Short form of Sergei, meaning 'victorious' |
| Serghei | Russian name meaning 'victorious' or 'triumphant' |
| Serj | Short form of Sergei, meaning 'victorious' |
| Sev | A short form of Seven, meaning the number seven. |
| Seyi | Yoruba name meaning 'gift of God' |
| Seymore | From Saint Maur |
| Shale | A Mountain Rock |
| Shanette | Loving will to Give All |
| Sharir | A name of Hebrew origin meaning the body. |
| Shark | Nickname for Sharon, meaning 'bitter' or 'fierce' |
| Shaven | Having a smooth, hairless surface, often referring to the head or face. |
| Shawnte | Place of Stones |
| Shayden | Variant of Hayden, meaning 'brilliant' or 'fiery'. |
| Shemar | A name meaning guardian or protected one. |
| Shenandoah | A name meaning daughter of the stars. |
| Shequille | The Royal Princes |
| Sheraan | Variant of Sheran, meaning 'peaceful' or 'tranquil'. |
| Sherrick | One who has Already Left |